kathy9
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Some people who have diabetes do not secrete insulin. Explain how a lack of insulin affects reabsorbtion of glucose in the kidneys of a person who does not secrete insulin. (4 marks)

Anybody able to talk me through the answer?
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macpatgh-Sheldon
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Hi,

a) Normally, virtually ALL glucose is reabsorbed in the early proximal tubule (there are only a few mg per dL in urine)
b) This is achieved by the action of SGLT 2 (sodium-dependent glucose transporter 2)
c) SGLT 2 transports glucose out of the proximal tubule into the renal interstitium in association with Na+ (= by secondary active transport)
d) When insulin is very deficient or absent, blood glucose rises and when it exceedss the renal threshold (180mg/dL), the reabsorption mechanism exceeds its transport maximum (Tm), and glucose appears in the urine (= glycosuria).

M
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macpatgh-Sheldon
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kathy9


Hi I have walked you through it above (wow - your hands are so small - sorry, its because mine are massive!)
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kathy9
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(Original post by macpatgh-Sheldon)
kathy9


Hi I have walked you through it above (wow - your hands are so small - sorry, its because mine are massive!)
thanks by the way, finished my a levels now yay! whats this about small hands?? lol
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macpatgh-Sheldon
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The "joke" was that if I were to literally walk you through the Q holding your hand, you would probs scream, which is what happens even to guys twice my size when we simply handshake!!
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