catwri1310
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When making monoclonal antibodies to direct a drug to a patients cells, scientists would not use B cells from the patients own body, Why?

Can anybody answer this thanks x
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macpatgh-Sheldon
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Firstly, this is not something they would expect you to know at A level by any standards, although it is a very interesting Q for academic inquiry and you obviously have a searching mind!

The reasons that one would not use the patient's own B cells to produce the antibody are twofold:

1. from natural extremely complex physiological characteristics, a patient's own cells are programmed to consider their own overall composition and antigenic make-up as self, so these cells will be "reluctant" to generate a monoclonal population of plasma cells that will attack its own kind.

2. if by an intricate mechanism, we were to manage to get the patient's own immune system to see its own cells as foreign, and thus create Ab-s against them, there is the risk of these Ab-s acting against the patient's normal cells, too, causing unwanted necrosis or even an auto-immune disease [you might know that the main application of monoclonal antibodies is in the treatment of cancer e.g. to make the drug imatizib [a tyrosine kinase inhibitor] target the neoplastic [Greek neo = new; plasm = life, so cancer] cells in preference to patient's normal dividing cells e.g. in the bone marrow.

M (clinical pharmacologist)
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catwri1310
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Thank you!
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