Hi,
It's risky looking too different, however thought I'd share the experience of a work placement friend of mine who has just finished her 'year in industry' work placement with a big pharma firm.
She put a couple of graphic designs (nice not tacky!) on the edges of hers. She got called to the assessment centre etc, got the job, beat off quite a bit of competition in doing so. When she started the job, the hiring Manager congratulated her on how her CV stood out from the rest. The Manager saw so many generic looking CV that my friends really jumped out at the hiring manager (obvs the content/skills/experience was good too!)
I must caveat this with it is just one story, as mentioned it might'nt be suitable for lots of companies and industries, but anything you can do to make your CV not just be another one in the generic pile is good I think!
Good Luck!
Paul