Alevel bio Watch

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Report Thread starter 9 months ago
Can I have some help with this questions pleaseeeee. Thanks

LD L cholesterol found in plasma binds to receptor proteins and is taken into cells by endocytosis.

A gene found on chromosome 19 is responsible for making LD L receptor proteins in human cell membranes.

*(a) F amilial hypercholesterolaemia (FH) is an inherited condition. The recessive allele (f) makes normal LD L receptor proteins.

The dominant allele (F) makes LD L receptor proteins that do not function.

Exp lain why people who inherit the dominant allele have an increased risk of
dying early.
Badges: 14
Report 9 months ago
LDL is what is referred to as “bad” cholesterol. If the dominant allele is present and LDL receptor proteins do not function, then less LDL cholesterol will be taken up into the cells by endocytosis. This means more LDL cholesterol will remain in the blood.

If more LDL cholesterol is in the blood it can lead to cardiovascular disease such as heart attack, and it increases the chances of developing atherosclerosis and arterial/venule thrombosis. Therefore, people with this “faulty” allele have an increased risk of developing these diseases or health complications and as such have an increased risk of a premature death.
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