A. Solis 99
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Does leukemia start in a single bone marrow or it involves all bone marrows of the body?
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great guy
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(Original post by A. Solis 99)
Does leukemia start in a single bone marrow or it involves all bone marrows of the body?
There are different types of leukaemia but the one you are talking about starts in a single bone marrow then spreads quickly to other regions of the body.
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Pearlfection1
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(Original post by A. Solis 99)
Does leukemia start in a single bone marrow or it involves all bone marrows of the body?
Depends on the type.

There are some which start on single bone marrow and progress to other parts of the body.
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nexttime
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Bone marrow is a tissue. Its not a single unit like an organ. Its like saying 'does eczema affects one skin or all of them?'.

Like all cancers, leukemia will start in a single cell and spread from there. By the time you have blasts in your blood (the definition of leukemia), it will be spread around all of your bone marrow yes.
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A. Solis 99
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(Original post by nexttime)
Bone marrow is a tissue. Its not a single unit like an organ. Its like saying 'does eczema affects one skin or all of them?'.

Like all cancers, leukemia will start in a single cell and spread from there. By the time you have blasts in your blood (the definition of leukemia), it will be spread around all of your bone marrow yes.
By that fact, why they were considering treating it with autologous BMT? (despite its not the best choice). Shouldnt all bone marrow of the body be defected?
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great guy
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(Original post by nexttime)
Bone marrow is a tissue. Its not a single unit like an organ. Its like saying 'does eczema affects one skin or all of them?'.

Like all cancers, leukemia will start in a single cell and spread from there. By the time you have blasts in your blood (the definition of leukemia), it will be spread around all of your bone marrow yes.
Exactly
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nexttime
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(Original post by A. Solis 99)
By that fact, why they were considering treating it with autologous BMT? (despite its not the best choice). Shouldnt all bone marrow of the body be defected?
You collect when in remission hope you don't pick up any of the leukemia cells. Emphasis on the 'hope' - its not a great treatment.

Also, you clearly don't know how bone marrow is collected for transplant. Look it up.
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A. Solis 99
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(Original post by nexttime)
You collect when in remission hope you don't pick up any of the leukemia cells. Emphasis on the 'hope' - its not a great treatment.

Also, you clearly don't know how bone marrow is collected for transplant. Look it up.
Thanks a lot for both answers.
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malkimoo
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what are the overall survival rates
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ecolier
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(Original post by malkimoo)
what are the overall survival rates
Couldn't you have done some research yourself?

Here is a wikipedia article for you to start on: https://en.wikipedia.org/wiki/Acute_leukemia
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nexttime
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(Original post by malkimoo)
what are the overall survival rates
Depends on the type. Google.
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Jpw1097
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(Original post by A. Solis 99)
By that fact, why they were considering treating it with autologous BMT? (despite its not the best choice). Shouldnt all bone marrow of the body be defected?
Also bear in mind that really, the main of aim of autologous stem cell transplants is to give a much higher dose of chemotherapy. The dose of chemotherapy given will completely wipe out the patients bone marrow, which would be irreversible and would be fatal if stem cells were not given to rescue the bone marrow. The autologous stem cell transplant is normally given as a consolidation therapy after a complete remission has been achieved (ideally), which by definition is when the bone marrow contains less than 5% blasts. However, patients in complete remission could still have a high tumour burden of up to 10^10 tumour cells! So autologous stem cell transplants aren’t really the best as it might not get rid of all the leukaemia cells. This is why allogeneic stem cell transplants are better, because the donors stem cells essentially attack and kill the leukaemia cells - this is known as graft-versus-leukaemia, it’s similar to graft-versus-host.
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