Theextremefish
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"Industrial preparation and testing of Aspirin.
Same method, larger scale described with a flow diagram (drying, filtering etc). Testing by IR spectroscopy and GL chromatography. NOTE; Tablet production is what happens to the Aspirin after manufacture so tablet production and testing is a small part of this, not all of it!" This is my P6 and i am really confused. Im not sure because it says tablets are a small part of this so i assume there is a powdered way of industrially producing Aspirin and i couldn't find anything please help!

Edit: the title should be industrial processing of aspirin as a powder
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Guarddyyy
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I'm not exactly sure what your question is or what you're trying to say. If you could make it clearer I can probably help out.
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Theextremefish
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(Original post by Guarddyyy)
I'm not exactly sure what your question is or what you're trying to say. If you could make it clearer I can probably help out.
In other words the preparation of aspirin, purification and testing but on a batch scale (i'm not sure what GL chromatography and IR spectroscopy is but it is a testing process) but my teacher told me that it wasn't the process for tablets but a different process.
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Guarddyyy
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So you're trying to test the purity of aspirin?
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Theextremefish
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(Original post by Guarddyyy)
So you're trying to test the purity of aspirin?
The whole process of making aspirin, purifying and testing basically everything XD. Maybe the way the teacher said it wasn't really right
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Guarddyyy
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Right, it makes more sense, so you want the entire process of making aspirin.

Procedure:

You would begin with oil of wintergreen which is the base product when making aspirin. You will need to reflux it with concentrated NaOH for around half an hour to ensure all of the oil of wintergreen has reacted.

You should then allow your mixture to cool by putting it surrounded by a large beaker of ice (but do not dilute the mixture). Slowly neutralise the mixture (then make slightly acidic) using 2mol dm^-3 of HCl and test the pH regularly using pH indicator paper.

Filter the solution to separate the 2-hydroxybenzoic acid and wash it with cold water to ensure all the acid is removed.

After that, you should get small amounts of ethanoic anhydride and concentrated sulfuric acid and gently shake it side to side for several minutes. Aspirin should begin to appear in the mixture. Add cold ethanoic acid and then filter off the solid product gently by filtrating and washing with ice cold water. Put it on a watch glass and allow it to dry.

Recrystallisation

Transfer most of your impure aspirin to a flask and gently heat ethanol is water using an electric bath. Add small amounts of the ethanol until the impure aspirin has fully dissolved. Cool slowly until crystals of aspirin form and put it in an ice-water bath. Filter the aspirin crystals gently and wash with ice-cold ethanol.

Allow the solid to dry on a watch glass.

Testing

Either use TLC (thin layer chromatography) and compare your product with known pure aspirin and 2-hydroxybenzoic acid or...

Melting point using a melting point tube. The purer it is, the closer it is should melt at the known melting point.



PHEEEEWW... that was a handful. I also forgot you should take mass measurements after each stage.

It's a ridiculously long practical (probably the longest, took me 3 lessons to complete which are 1h 30m long).
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Guarddyyy
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Sad part is you need to memorise this.
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Theextremefish
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(Original post by Guarddyyy)
Sad part is you need to memorise this.
TYVM and yea ;-;
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