I was wearing glasses during biology and chemestry labs, mostly wearing progressives (verifocal). When using the microscope I sometimes asked for the one with an adjustable eyepiece where you can set your prescription to help you focus without glasses. It goes from +4 to -4 so it covers most of the prescriptions, we had a few in our lab, if non were available I'd manage because I see pretty well just had a bit less fun staring at a not so clear cells. Well, it all depends on how blurry and unfocused is your eyesight.
I used rimless frames so it was very easy to put the googles on top of them, I even wore sunglasses on top of them sometimes so lab googles were pretty comfortable, 3D glasses on the other hand weren't comfortable at all.
If your lenses are high quality the transition between near and far point and the mid range should be fine, if you expreince some sort of dificulty you may consider office lenses.
Disclamer - I'm an optoetrist.