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Report Thread starter 8 months ago
hi, does anyone have straight forward method of how to make 10grams of paracetamol in a lab
Kian Stevens
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Report 7 months ago
The synthesis itself is relatively straightforward.
A word of warning: I'm not going to give precise reagent masses as the reaction's efficiency is dependent on the chemist, as well as the reaction itself. Hence, the masses will be a rough guide.

  1. Add 4-aminophenol (\approx 15 g) to a conical flask, dissolve in deionised water and add acetic anhydride (\approx15 cm3); swirl this mixture,
  2. Heat the mixture in a high-temperature bain-marie for a good 10 minutes whilst periodically swirling the flask, and then place into an ice bath to allow the mixture to crystallise out,
  3. Filter this precipitate using reduced pressure filtration (i.e. Büchner funnel),
  4. Recrystallise the mixture in the minimum amount of hot solvent (i.e. water),
  5. Allow the mixture to crystallise out by just leaving it to cool to room temperature, before placing into an ice bath,
  6. Filter the precipitate using reduced pressure again,
  7. Dry the solid to constant mass in a low heat oven.

The solid left behind will be paracetamol.
Last edited by Kian Stevens; 7 months ago

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