synthesis of paracetamol Watch
A word of warning: I'm not going to give precise reagent masses as the reaction's efficiency is dependent on the chemist, as well as the reaction itself. Hence, the masses will be a rough guide.
- Add 4-aminophenol ( 15 g) to a conical flask, dissolve in deionised water and add acetic anhydride (15 cm3); swirl this mixture,
- Heat the mixture in a high-temperature bain-marie for a good 10 minutes whilst periodically swirling the flask, and then place into an ice bath to allow the mixture to crystallise out,
- Filter this precipitate using reduced pressure filtration (i.e. Büchner funnel),
- Recrystallise the mixture in the minimum amount of hot solvent (i.e. water),
- Allow the mixture to crystallise out by just leaving it to cool to room temperature, before placing into an ice bath,
- Filter the precipitate using reduced pressure again,
- Dry the solid to constant mass in a low heat oven.
The solid left behind will be paracetamol.