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This decline in antibiotic development was due to decreasing antibiotic research and development in major pharmaceutical companies; investment in new antibiotic development has been hampered by the uncertain lifecycles (associated with antibiotic resistance development) of new antibiotic drugs and government regulations affecting the pace of translational exploitation.

From the article: Bacteria Antibiotic Resistance: New Challenges and Opportunities for Implant-Associated Orthopaedic Infections

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Less antibiotics because less research, less research because resistance makes the profit uncertain and because of government bureaucracy and regulation.

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