suzannehamid
Badges: 2
Rep:
?
#1
Report Thread starter 1 year ago
#1
Describe how the base change in DNA results in a fault protein molecule being made, that prodcues the condition of sickle cell anemia?

Explain the inheritance pattern of the condition, giving examples using completed genetic diagrams?

( any help with these questions much appreciated) - guidelines to include diagrams of nucleic acis, protein synthesis and Mendelian inheritance in 1500 words...... )
0
reply
Js048326
Badges: 11
Rep:
?
#2
Report 1 year ago
#2
For the first one you could talk about how a base deletion (which leads to a frame shift) or substitution leads to a different amino acid being produced which changes the primary sequence of protein which changes the tertiary structure of protein which in turn changes the quaternary structure of the red blood cells so they are different shapes and can no longer carry out their functions properly (carrying O2)
0
reply
Jpw1097
Badges: 18
Rep:
?
#3
Report 1 year ago
#3
(Original post by suzannehamid)
Describe how the base change in DNA results in a fault protein molecule being made, that prodcues the condition of sickle cell anemia?

Explain the inheritance pattern of the condition, giving examples using completed genetic diagrams?

( any help with these questions much appreciated) - guidelines to include diagrams of nucleic acis, protein synthesis and Mendelian inheritance in 1500 words...... )
Sickle cell disease is caused by a point mutation causing the amino acid in the sixth position to change from glutamate (a hydrophilic amino acid) to valine (a hydrophobic amino acid). In the deoxygenated state, haemoglobin has a hydrophobic pocket which glutamate does not bind to, however, valine binds to the hydrophobic pocket as it is a hydrophobic amino acid, causing haemoglobin molecules to stick together forming long polymers. This causes the RBCs to become sickle shaped and less flexible, causing them to block capillaries and cause vaso-occlusive crises.

Sickle cell disease is an autosomal recessive disorder, although even having a single allele can produce mild symptoms (sickle cell trait).

That's as much as I'm going to give you. This and everything else can be found easily online.
0
reply
X

Quick Reply

Attached files
Write a reply...
Reply
new posts
Back
to top
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise

What would make a great online university open day?

Virtual campus tour (54)
19.57%
Virtual accommodation tour (37)
13.41%
Find out about sports clubs, societies and facilities (13)
4.71%
Video content about the local area (2)
0.72%
Webinars with lecturers (10)
3.62%
Taster lectures or seminars (64)
23.19%
Speak to current students studying my course (59)
21.38%
Speak to current students about the uni in general (11)
3.99%
Fun online activities or experiences (10)
3.62%
Connecting with careers services or employers (7)
2.54%
Info about student wellbeing and support services (4)
1.45%
Something else (let us know in the thread!) (5)
1.81%

Watched Threads

View All