Why are female gametes more prone to non-disjunctions compared to male ones? Watch

shankar jan
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Please share your thoughts
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R T
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Probably because female gametes are much older than male. Sperm is made continuously from "freshly" dividing stem-like cells. The life cycle of a sperm is typically a few days. Oocytes develop in female mammals from a very very young age, and will later mature into gametes after (in some cases) many years.

Cellular machinery (not just DNA but actin and other proteins) does degrade with time. Most biochemical molecules do not have particularly long half lives even in isolation and rely on repair mechanisms to continue to function. The age of oocytes likely makes problems and mistake during meiosis more common. Clearly the failure rate is not high enough to cause serious reproductive problems in the majority of cases.
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Jpw1097
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(Original post by R T)
Probably because female gametes are much older than male. Sperm is made continuously from "freshly" dividing stem-like cells. The life cycle of a sperm is typically a few days. Oocytes develop in female mammals from a very very young age, and will later mature into gametes after (in some cases) many years.

Cellular machinery (not just DNA but actin and other proteins) does degrade with time. Most biochemical molecules do not have particularly long half lives even in isolation and rely on repair mechanisms to continue to function. The age of oocytes likely makes problems and mistake during meiosis more common. Clearly the failure rate is not high enough to cause serious reproductive problems in the majority of cases.
Exactly, the machinery involved in separating chromosomes/chromatids (such as the spindle apparatus) degrade over time.
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shankar jan
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Thanks so much R T and Jpw1097
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