username4933904
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Does anyone understand why serum [urea] rises in acute pancreatitis? Is it simply because of dehydration associated with fluid release? Or is it increased proteolysis?
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macpatgh-Sheldon
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Hi,

A rise in serum urea is not a hallmark finding in acute pancreatitis as such (in which, of course, pancreatic amylase and lipase levels can be 3 times normal, hypocalcaemia occurs, and LFTs can be abnormal (hyperbilirubinaemia, and elevated alkaline phosphatase and AST levels)); however, organ failure can be a complication and is a negative prognostic factor, and, of course, if renal failure occurs, serum urea (as well as creatinine) will be high.

Although in theory, proteolysis might lead to increased production of urea via the ornithine-arginine cycle, I am not sure this would be severe enough to result in raised serum levels in the presence of normal renal function.

Hope this helps.
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nexttime
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Never heard of this as a specific association.

Of course it might happen if the patients develops renal failure as a secondary consequence.
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