JanaALEVEL
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If DNA was used to make RNA and then, instead of that RNA forming proteins, it went on to have other functions, would this be called gene expression ? Or is it a must for proteins to be synthesized ?
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vk0109
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Hi,
DNA to RNA and then to proteins is mostly the initial product formed but not necessarily as it can form other non-coding RNAs as well. these ncRNA (non-coding) are transcribed from DNA but do not translate into proteins. And yes, this could be related to gene expression4

Hope this helped

Vini
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macpatgh-Sheldon
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Hi let me try to help you with this, although this is an extremely complex area with mind-blowing research currently in progress, so please forgive me if my info is already outdated as I type!

Gene expression occurs at one or more of several levels:

DNA synthesis
Transcription (RNA formation)
Postranscriptional modification of RNA
Translation (protein synthesis)
Postranslational processing.

Gene expression (activated by gene promoters or the opposite = gene silencing) is brought about by the regulation of gene expression by transcription factors. The latter bind to DNA sequences in the regulatory regions of genes. e.g. gene silencing can be brought about by methylation of DNA (addition of methyl groups [-CH3]). One other mechanism is the action of a "poly-A tail" (produced by the addition of several adenyl groups), which can modify the transport of mRNA to the cytoplasm, and hence influence translation.

Therefore, No, "it is not a must for proteins to be synthesized".

Google Prader-Willi syndrome, genomic imprinting and the Lyon hypothesis for examples of diseases caused by abnormal gene expression and their explanation.

Hope this helps!
M (specialist biology tutor)
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tocka90
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https://www.youtube.com/channel/UCQX...AnOAPVBv-QRNTQ look here in section 8. A lot on gene expression for AQA A level Biology
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