Can somebody explain the role of Carbohydrates in the membrane to me ?

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VeryNewMedic
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My book says that the importance of carbohydrates in membranes is
a) Mediating the interactions of a cell with its environment.
b) Sorting membrane proteins to different cellular compartments.

I don't understand how it does the latter
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RainThorn
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(Original post by VeryNewMedic)
My book says that the importance of carbohydrates in membranes is
a) Mediating the interactions of a cell with its environment.
b) Sorting membrane proteins to different cellular compartments.

I don't understand how it does the latter
May I ask what level of study you are at (GCSE or equiv, A level or equiv etc) just so I dont give you too much information?
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VeryNewMedic
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(Original post by RainThorn)
May I ask what level of study you are at (GCSE or equiv, A level or equiv etc) just so I dont give you too much information?
I am a 1st year med student and this is from my cytology class.
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RainThorn
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(Original post by VeryNewMedic)
I am a 1st year med student and this is from my cytology class.
Ahhh gotcha, Im first year biomed so ill help the best I can but from the top of my head it is based on glycoproteins and glycolipids allowing adhesion relative to the fluid mosaic model. This allows compartmentation as well as fluidity.
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macpatgh-Sheldon
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(Original post by VeryNewMedic)
My book says that the importance of carbohydrates in membranes is
a) Mediating the interactions of a cell with its environment.
b) Sorting membrane proteins to different cellular compartments.

I don't understand how it does the latter
Hi,

Let me try to guide you. I think your book is referring to some particular aspects of the function of carbohydrates in the cell membrane, because most channels and specific exchange sites for substances are proteins, and the lipds/cholesterol in the membrane selectively permit movement of lipophilic substances. The only carbohydrates I can think of are some of the glycoproteins [of course, protein moieties attached to a carbohydrate portion in the Golgi], such as the ABC [ATP binding cassette proteins] including the glycoproteins called multidrug transporters, which play a part in the movement of drugs and some cations across cell compartments, particularly in the liver and the kidney.{the ones found in the desmosomes e.g. cadherins and Ig-CAMs (cell adhesion molecules) are more to do with cell adhesion - The cadherins are calcium dependent, whereas the Ig-CAMs are calcium independent.}.

The other point that comes to mind is the CFTR protein, an abnormality of which, genetically transmitted as an autosomal recessive trait, is cystic fibrosis, in which there is a defect in the movement of Cl- anion across membranes in the lungs, pancreas and in the testes, leading to severe respiratory infections [due to production of thick mucus], failure of protein digestion [lack of trypsin and chymotrypsin] and infertility, respectively.

{Other carbohydrate-containing molecules are the proteoglycans like GAGs [glycosaminoglycans] e.g. proteoglycan chondroitin sulphate and proteoglycan dermatan sulphate, which can determine the nature of substances passing through the membrane, particularly in connective tissue - this might be relevant to the function of osteoblast-type cells in bone}.

I hope this helps!
M.
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macpatgh-Sheldon
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@VeryNewMedic

Hi there! Firstly I hope you and your family/friends are all ok in this turn of tables on our planet (COVID-19), and my best wishes extend to all members, staff, helpers at TSR and to humankind.

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More to follow plus some equations.
Have a nerdy evening - soooorry!
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macpatgh-Sheldon
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VeryNewMedic

Chk above
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lyer_in_hellfyre
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(Original post by macpatgh-Sheldon)
@VeryNewMedic

Hi there! Firstly I hope you and your family/friends are all ok in this turn of tables on our planet (COVID-19), and my best wishes extend to all members, staff, helpers at TSR and to humankind.

Other readers of this message pls forgive me for an apparently irrelevant post but this is cos of the limitations in the message systemName:  IMG_20200322_190439.jpg
Views: 12
Size:  108.0 KB on TSR.

V.N. Medic, here are the pics I promised.


Name:  IMG_20200322_190256.jpg
Views: 13
Size:  122.5 KB
More to follow plus some equations.
Have a nerdy evening - soooorry!
They're very relevant and helpful if you'd ask me :ta:
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VeryNewMedic
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(Original post by macpatgh-Sheldon)
@VeryNewMedic

Hi there! Firstly I hope you and your family/friends are all ok in this turn of tables on our planet (COVID-19), and my best wishes extend to all members, staff, helpers at TSR and to humankind.

Other readers of this message pls forgive me for an apparently irrelevant post but this is cos of the limitations in the message systemName:  IMG_20200322_190439.jpg
Views: 12
Size:  108.0 KB on TSR.

V.N. Medic, here are the pics I promised.


Name:  IMG_20200322_190256.jpg
Views: 13
Size:  122.5 KB
More to follow plus some equations.
Have a nerdy evening - soooorry!
I had a nerdy evening.
Thank you very much
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