TheKitty.x
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Last edited by TheKitty.x; 4 months ago
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HarisMalik98
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The drug is causing uncoupling which disrupts the H+ gradient. This means no ATP can be produced via ATP synthase.

Therefore, the body needs to metabolise more sugar and fats for energy requirements. It is essentially increasing the BMR of the individual. This facilitates the weight loss.

However, lowering ATP production is a very dangerous thing to do - and maintaining the balance between 'just enough ATP' and not enough is probably no more than a small difference in the dose of the drug. That's why it's dangerous.
Last edited by HarisMalik98; 4 months ago
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TheKitty.x
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(Original post by HarisMalik98)
The drug is causing uncoupling which disrupts the H+ gradient. This means no ATP can be produced via ATP synthase.

Therefore, the body needs to metabolise more sugar and fats for energy requirements. It is essentially increasing the BMR of the individual. This facilitates the weight loss.

However, lowering ATP production is a very dangerous thing to do - and maintaining the balance between 'just enough ATP' and not enough is probably no more than a small difference in the dose of the drug. That's why it's dangerous.
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Richard191
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A. Uncoupling the electron transport chain would inhibit fermentation and decrease ATP production, a potentially dangerous situation.
B. If electron transport doesn't produce ATP, then much more sugar must be metabolized for energy needs. Very low production of ATP would be lethal.
In oxidative phosphorylation, the flow of electrons from NADH and FADH2 to oxygen results in the pumping of H+ from the matrix to the inner membrane space. This gradient of H+ can produce ATP by flowing through ATP synthetase in the mitochondrial inner membrane. Dinitrophenol disrupts the H+ gradient reducing ATP synthesis. Under these conditions, much of the food that we eat could not be used for ATP synthesis are we lose weight. However, too much inhibitor and we could make too little ATP for life. The difference between weight loss and death is only a small concentration change in dinitrophenol, making the drug dangerous.
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