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What is the maximum number of double-strand breaks DNA in a nucleus can take before the cell begins to form a tumour?

Is there a maximum?

Where can I find more info about this?

Thank you so much in advance
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(Original post by aroundanaxis)
What is the maximum number of double-strand breaks DNA in a nucleus can take before the cell begins to form a tumour?

Is there a maximum?

Where can I find more info about this?

Thank you so much in advance
There isn’t a specific number of double strand breaks that cause tumour development. Tumour is not an all-or-nothing process, but rather is caused by the accumulation of mutations in various genes, in particular those that code for proteins that regulate the cell cycle, as well as tumour suppressor genes.

Bear in mind that it’s not the double strand break itself that results in mutations, it’s actually due to the repair mechanisms which do not repair the breaks 100% accurately.
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