Fareeha18
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Can someone help me with this question,please?
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macpatgh-Sheldon
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Hi there, sorry you have had no answer after so long ,

I am happy to help you out here - it would be useful to know what level you are studying at, so that I can provide the right level of detail.

In the meantime, assuming you are at A level, I think all you would need to know is that the stem cell here is the haematopoietic stem cell [HSC] in the bone marrow [mostly of long bones e.g. femur]; there are two types of these: lymphoid and myeloid - the latter are capable of differentiation into erythrocytes and platelet precursors [dw about complex names unless you are doing a degree - if so please PM me].

After commitment to the RBC lineage i.e. once a HSC is differentiated enough to follow the myeloid route, it will transform into a proerythroblast [pro means first as in prototype in ordinary English - the syllable "blast" refers to immature cells]. After that the cell's nucleus migrates to the periphery and is extruded. The resulting enucleated cell [without a nucleus] is called a reticulocyte. Durinhg this time transcription leading to protein synthesis shifts from the production of membrane proteins like spectrin to that of haemoglobin. [For A* in the synopsis Q: the vast majority of the haemoglobin in an adult is Hb A [which has two alpha chains and two beta chains of the protein globin], but a small amount of foetal Hb [Hb F] persists - this latter has two alpha chains and two gamma chains - foetal Hb has a greater affinity for oxygen as it has to "steal" oxygen from the pregnant mother's blood].

The final stage is the maturation of a fully functional erythrocyte, which has a lifespan of about 90 days.
The importance of knowing the above is to understand the pathophysiology [altered function in disease] of e.g. aplastic anaemia [in which there is deficient RBC production], and its treatment by bone marrow transplantation.

(Also google "erythropoietin")

M [specialist biology tutor]
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macpatgh-Sheldon
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Fareeha18

Hellllloooooo! Answer for you above!
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Fareeha18
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(Original post by macpatgh-Sheldon)
Fareeha18

Hellllloooooo! Answer for you above!
Hey! Thank you so much for explaining it so well
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