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what causes genetic disorders?
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title. could it be your parents are cousins (in my case mums dad and dads dad are brothers, making them very close cousins) hence why out of the 5 children I came out with a genetic disorder? and my grandparents are also cousins but I can’t explain the relation. In Islam cousin relationships are allowed. Did something happen during sex which causes these things?
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#2
Most serious genetic disorders are resesive, this means that you need two coppies of the same faulty gene to suffer with it.
Your parents share around 12.5% of their DNA. Also one set of your grandparents also shared 12.5% of their DNA.
This massively increases the likelyhood of their offspring (children) inheriting 2 copies of the same faulty gene- for over 6% of the offsprings genetic code, they will have 2 identical copies of the same gene.
It's not about how they had sex, it's about who they had sex with.
Your parents share around 12.5% of their DNA. Also one set of your grandparents also shared 12.5% of their DNA.
This massively increases the likelyhood of their offspring (children) inheriting 2 copies of the same faulty gene- for over 6% of the offsprings genetic code, they will have 2 identical copies of the same gene.
It's not about how they had sex, it's about who they had sex with.
Last edited by glassalice; 4 months ago
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(Original post by glassalice)
Most serious genetic disorders are resesive, this means that you need two coppies of the same faulty gene to suffer with it.
Your parents share around 12.5% of their DNA. Also one set of your grandparents also shared 12.5% of their DNA.
This massively increases the likelyhood of their offspring (children) inheriting 2 copies of the same faulty gene- for over 6% of the offsprings genetic code, they will have 2 identical copies of the same gene.
It's not about how they had sex, it's about who they had sex with.
Most serious genetic disorders are resesive, this means that you need two coppies of the same faulty gene to suffer with it.
Your parents share around 12.5% of their DNA. Also one set of your grandparents also shared 12.5% of their DNA.
This massively increases the likelyhood of their offspring (children) inheriting 2 copies of the same faulty gene- for over 6% of the offsprings genetic code, they will have 2 identical copies of the same gene.
It's not about how they had sex, it's about who they had sex with.
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#4
Very few serious genetic disorders are caused by a dominant gene.
If your siblings where suffering from a genetic disorder caused by a dominant gene, at least on of your parents and one of your grandparents would be symptomatic.
If your siblings where suffering from a genetic disorder caused by a dominant gene, at least on of your parents and one of your grandparents would be symptomatic.
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(Original post by glassalice)
Very few serious genetic disorders are caused by a dominant gene.
If your siblings where suffering from a genetic disorder caused by a dominant gene, at least on of your parents and one of your grandparents would be symptomatic.
Very few serious genetic disorders are caused by a dominant gene.
If your siblings where suffering from a genetic disorder caused by a dominant gene, at least on of your parents and one of your grandparents would be symptomatic.
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#6
They aren't disallowed in other religions or cultures, but they aren't encouraged either, for the very reasons you asked. There have been several TV programmes about multi generational inter-cousin marriage, and the statistics of having children with genetic issues increases as the gene pool gets smaller. The programme I saw was very sad.
Last edited by Nautilus; 4 months ago
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(Original post by Nautilus)
I hope you don't mind me asking, but do you blame your parents?
I hope you don't mind me asking, but do you blame your parents?
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(Original post by Nautilus)
I hope you don't mind me asking, but do you blame your parents?
I hope you don't mind me asking, but do you blame your parents?
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#11
In some cases genetic disorders can be caused by spontaneous mutations, given your family history that is unlikely.
If your disease was caused by a dominant gene, one of your parents would also have that disease. Ie. They passed the disease down to you.
If your disease was caused by a recessive gene, both of your parents must be at least carriers. Carriers are non symptomatic.
The ill effects of interbreeding have been observed and recorded throughout history.
Is there someone who you talk about this to?
If your disease was caused by a dominant gene, one of your parents would also have that disease. Ie. They passed the disease down to you.
If your disease was caused by a recessive gene, both of your parents must be at least carriers. Carriers are non symptomatic.
The ill effects of interbreeding have been observed and recorded throughout history.
Is there someone who you talk about this to?
Last edited by glassalice; 4 months ago
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#12
maybe your parents haven't heard of Charles II of Spain who was the product of decades of inbreeding done by the Hapsburg royals in order to prevent their royal blood from being tainted. He was, according to karger.com, physically disabled, disfigured, mentally ******ed, and he proved impotent. He had an inbreeding coefficient of .25, about the same as (or even higher than) that of an offspring from parents who're frickin siblings. They should (no offense) read more articles about the impact of inbreeding, both negative and positive (well, mostly negative), on the offspring.
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(Original post by glassalice)
In some cases genetic disorders can be caused by spontaneous mutations, given your family history that is unlikely.
If your disease was caused by a dominant gene, one of your parents would also have that disease. Ie. They passed the disease down to you.
If your disease was caused by a recessive gene, both of your parents must be at least carriers. Carriers are non symptomatic.
The ill effects of interbreeding have been observed and recorded throughout history.
Is there someone who you talk about this to?
In some cases genetic disorders can be caused by spontaneous mutations, given your family history that is unlikely.
If your disease was caused by a dominant gene, one of your parents would also have that disease. Ie. They passed the disease down to you.
If your disease was caused by a recessive gene, both of your parents must be at least carriers. Carriers are non symptomatic.
The ill effects of interbreeding have been observed and recorded throughout history.
Is there someone who you talk about this to?
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#14
I'm sorry that your parents aren't being very nice. I think they are being defensive because they feel guilty. It sounds like they could possibly be carriers of these defective genes. You sound like you have done a lot of reading around the subject. Are you able to talk to the doctor without either of your parents being present?
Last edited by Nautilus; 4 months ago
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what about things like sickle cell anaemia? a girl died at 17, not sure if she blamed her parents or if they were related or anything, don’t think they were, she was half muslim, half jew, half christian, half african and goes on.
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(Original post by Nautilus)
I'm sorry that your parents aren't being very nice. I think they are being defensive because they feel guilty. It sounds like they could pssibly be carriers of these defective genes. You sound like you have done a lot of reading around the subject. Are you able to talk to the doctor without either of your parents being present?
I'm sorry that your parents aren't being very nice. I think they are being defensive because they feel guilty. It sounds like they could pssibly be carriers of these defective genes. You sound like you have done a lot of reading around the subject. Are you able to talk to the doctor without either of your parents being present?
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#17
Like someone else has said, you should speak to a doctor when you have the chance, they will have far more answers for you, than anyone on here.
I wish you look.
I wish you look.
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I must say though, my disorder is the best disorder that you can have, if you had to pick a genetic condition, this is the best one as it doesn’t kill you and a normal SGA person goes through the same thing as someone with this genetic defect, but obviously we go through a tiny bit more. Its just the average feeding difficulties, failure to meet developmental milestones, pre-natal and postnatal growth failure and recurring episodes of hypoglycaemia. First 7 years was tough for me, followed by 3 that weren’t so bad then medical appointments stopped.
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#19
Can you eat normally now?
You write very well, and are articulate. You must have done well at school.
You write very well, and are articulate. You must have done well at school.
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(Original post by Nautilus)
Can you eat normally now?
You write very well, and are articulate. You must have done well at school.
Can you eat normally now?
You write very well, and are articulate. You must have done well at school.
Thank you, I did do well but struggled with one of my AS levels.
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