John LR
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Hi,
Stuck on the Cascade where co-enzyme 5 is modified by thrombin (undergoes cleavage), the now modified co-enzyme 5 can do what co-enzymes do best and bond with factor 10 (which already been activated by factor 7 and 9).

The now activated 10, with the modified co-enzyme 5, can get to work on Pro-thrombin, producing that all important thrombin !

But in order for co-enzyme 5 to work on factor 10, it need to be modified (cleavage) by Thrombin - and for thrombin to be produced it needs factor 10 (with the help of modified co-enzyme factor 5)

So what you end up with is no thrombin, no modified co-factor 5, which means no workable factor 10, which means no Thrombin.

What am I missing - can factor 10 work in creating thrombin without co-enzyme 5 - is it something like that - where co-enzyme 5 not vital just make everything more efficient ?

Anyone knows - John
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Jpw1097
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(Original post by John LR)
Hi,
Stuck on the Cascade where co-enzyme 5 is modified by thrombin (undergoes cleavage), the now modified co-enzyme 5 can do what co-enzymes do best and bond with factor 10 (which already been activated by factor 7 and 9).

The now activated 10, with the modified co-enzyme 5, can get to work on Pro-thrombin, producing that all important thrombin !

But in order for co-enzyme 5 to work on factor 10, it need to be modified (cleavage) by Thrombin - and for thrombin to be produced it needs factor 10 (with the help of modified co-enzyme factor 5)

So what you end up with is no thrombin, no modified co-factor 5, which means no workable factor 10, which means no Thrombin.

What am I missing - can factor 10 work in creating thrombin without co-enzyme 5 - is it something like that - where co-enzyme 5 not vital just make everything more efficient ?

Anyone knows - John
I understand your confusion, it’s a bit like which came first, the chicken or the egg. I think you’re getting too caught up in the details. The truth is, there is always going to be some activated factor V (FVa) and there is always going to be some activated thrombin, it’s not as though there is absolutely no activated FVa or thrombin around.

By the way, I would call factor V co-enzyme V, I’ve never heard it being referred to that way.
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