Are glycoproteins Intrinsic (integral) or extrinsic (peripheral)

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Biology--Guy
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#1
Report Thread starter 7 months ago
#1
Hello,

I was going through the OCR textbook in Biology and noticed that and noticed that glycoproteins in the plasma membranes were described as extrinsic. Is this true?

I have looked around and most diagrams tend to vary in terms of the position of glycoproteins in membranes.

Thanks,

Biology--Guy
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anosmianAcrimony
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#2
Report 7 months ago
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Glycoproteins - that is, proteins with carbohydrate groups attached - are very common; a lot of proteins that do a lot of jobs have carbohydrate groups attached to them. But glycoproteins do carry out very important roles on the cell surface, mostly to do with cell signalling and recognition of self versus foreign. The ones that do that face outward.
Last edited by anosmianAcrimony; 7 months ago
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Biology--Guy
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#3
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So they are extrinsic?
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macpatgh-Sheldon
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They are mostly transmembrane or integral.

EXAMPLE: The beta subunit of Na+,K+ - ATPase [sodium-potassium pump, which exchanges 3 Na+ ions for 2 K+ ions] is a glycoprotein, part of which is membrane-spanning - the carbohydrate residues, although attached to the whole moiety, are extracellular.,
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username4218074
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#5
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(Original post by macpatgh-Sheldon)
They are mostly transmembrane or integral.

EXAMPLE: The beta subunit of Na+,K+ - ATPase [sodium-potassium pump, which exchanges 3 Na+ ions for 2 K+ ions] is a glycoprotein, part of which is membrane-spanning - the carbohydrate residues, although attached to the whole moiety, are extracellular.,
If I'm honest, whilst I agree, for the sake of mark schemes I would assume they're peripheral. That's how they were on my a-level spec
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