What factors must be considered when comparing two treatments for a disease?

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2026_helia
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#1
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#1
I have brainstormed the following;
- cost effectiveness
- longevity of effect(s) - short and long term, on physcial and mental well being, such as side effects and benefits
- accessibility
- the target population - if everyone can use it, if not why not, what types of people are compatible with this type of treatment
Is there any more, do you think? If so, could you kindly let me know?
I'm writing a dissertation on comparing the treatments LCIG (Levodopa-carbidopa Intestinal Gel) and DBS (Deep Brain Stimulation), on parkinsonson disease.

thank you very much!
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lilGem
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#2
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You could look at things like:
Efficacy
Speed of onset of action
Safety profile
Route of administration- how could this affect QoL
How much would it prevent disease progression- you can probably go into a lot of depth
patient reported outcomes- patients perspectives after receiving treatments (which are often quantified via surveys)
Any co-morbidities or risk factors
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2026_helia
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#3
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#3
(Original post by lilGem)
You could look at things like:
Efficacy
Speed of onset of action
Safety profile
Route of administration- how could this affect QoL
How much would it prevent disease progression- you can probably go into a lot of depth
patient reported outcomes- patients perspectives after receiving treatments (which are often quantified via surveys)
Any co-morbidities or risk factors
Hello
thank you very much for this, I have a few questions for you; what do you mean by QoL?
for preventing disease progression - this is a noncommunicable disease therefore it cannot spread, and there is no current way of prevention of Parkinsons, only symptomatic treatments - there is no current cure for parkinsons. So if this is what you mean by how much it prevents disease, I think we can agree I can safely cross that factor out?
Also, how can I be aware if I've included all the necessary factors I need to evaluate?
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lilGem
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(Original post by 2026_helia)
Hello
thank you very much for this, I have a few questions for you; what do you mean by QoL?
for preventing disease progression - this is a noncommunicable disease therefore it cannot spread, and there is no current way of prevention of Parkinsons, only symptomatic treatments - there is no current cure for parkinsons. So if this is what you mean by how much it prevents disease, I think we can agree I can safely cross that factor out?
Also, how can I be aware if I've included all the necessary factors I need to evaluate?
QoL= Quality of Life

I am also well aware that it is a noncommunicable disease. By disease progression I mean mild, moderate or advanced stages and how quickly or slowly patients 'progress' through these stages

If you look at clinical trials or current reviews of treatments for Parkinson's it can help give you an idea of how data is compared in the real world and how this is measured.
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