kierab22
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i was watching one of my biochem lectures and they started talking about single stranded DNA (ssDNA). the whole of a level i've only known it to be found as a double helix (ie dsDNA) and only exists as a single strand during DNA replication.
is this the only time it's found or do you get ssDNA outside of those processes?
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macpatgh-Sheldon
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Hi young man [Kieran?] - hope you are well!

ssDNA is rare in nature, and only occurs, as far as I know [even Sheldon is struggling here - v good Q!] only as the genetic material of certain viruses, notably those of the Family Parvoviridae [commonly referred to as parvoviruses].

randombiochemist: are you able to add more detail, please?

M
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FelineImplant
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(Original post by kierab22)
i was watching one of my biochem lectures and they started talking about single stranded DNA (ssDNA). the whole of a level i've only known it to be found as a double helix (ie dsDNA) and only exists as a single strand during DNA replication.
is this the only time it's found or do you get ssDNA outside of those processes?
It is not only during DNA replication as it also occurs during gene transcription when the RNA polymerase forms the open complex. It can occur randomly throughout the DNA as it forms melting bubbles (pockets of ssDNA) in response to torsional stress. The highest forces on DNA occur during anaphase. Here is a paper that you might find interesting about the different forms of DNA https://pubmed.ncbi.nlm.nih.gov/23431161/*
*this includes S DNA which is neither ssDNA nor standard B DNA
Last edited by FelineImplant; 1 month ago
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