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zarahh09
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Explain how analysing the mRNA of stem cells and differentiated cells enable us to identify the deactivated genes ??
Anyone? I am stuck
Anyone? I am stuck
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macpatgh-Sheldon
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Sorry to hear you are stuck in the mongrove swamps of the Rift Valley Province - dw I was born there so will find a way to rescue you!! If I need to drive to Kenya via Spain, Tunisia, SE to Sudan, then Somalia then N Kenya, then so be it lol 
[airplanes are out of action r n due to the curse placed by the supreme manager!!]
Keep laughing everyone!
Coming to your Q, in the last several years, we have discovered a massive amount of detail on mRNA function, gene suppression, transcription factors, mRNA degradation, etc.
For A level, it might be wise just to say:-
a) that we now have ways of working out the full base sequences of mRNA [and other nucleic acids oc].
b) the mRNA of stem cells [which can be pluripotent - can develop into various tissue/cell types] there will be greater degree of ability to lead to translation of a large no. of proteins.
c) mRNA of differentiated cells will have shorter mRNAs coding for less proteins e.g. a cell once already "committed" to become an erythrocyte will have mRNA to code for haemoglobin, WHEREAS a cell destined to become a phagocyte will have genetic material top synthesize lysosomal enzymes [e.g. proteases + nucleases] to destroy ingested bacteria.
d) we can now trace the processes in the 1st 2 lines above to distinguish between stem cell mRNA and differentiated cell mRNA.
I am not sure what the latest A level biology specs for the various boards require on this topic, so please check the spec of your board.
Be safe!
M.
[airplanes are out of action r n due to the curse placed by the supreme manager!!]Keep laughing everyone!
Coming to your Q, in the last several years, we have discovered a massive amount of detail on mRNA function, gene suppression, transcription factors, mRNA degradation, etc.
For A level, it might be wise just to say:-
a) that we now have ways of working out the full base sequences of mRNA [and other nucleic acids oc].
b) the mRNA of stem cells [which can be pluripotent - can develop into various tissue/cell types] there will be greater degree of ability to lead to translation of a large no. of proteins.
c) mRNA of differentiated cells will have shorter mRNAs coding for less proteins e.g. a cell once already "committed" to become an erythrocyte will have mRNA to code for haemoglobin, WHEREAS a cell destined to become a phagocyte will have genetic material top synthesize lysosomal enzymes [e.g. proteases + nucleases] to destroy ingested bacteria.
d) we can now trace the processes in the 1st 2 lines above to distinguish between stem cell mRNA and differentiated cell mRNA.
I am not sure what the latest A level biology specs for the various boards require on this topic, so please check the spec of your board.
Be safe!
M.
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Jpw1097
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(Original post by zarahh09)
Explain how analysing the mRNA of stem cells and differentiated cells enable us to identify the deactivated genes ??
Anyone? I am stuck
Explain how analysing the mRNA of stem cells and differentiated cells enable us to identify the deactivated genes ??
Anyone? I am stuck
Methods for quantifying the entire transcriptome (that is, mRNA levels for all genes) including RNA sequencing or RNA micro-arrays.
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