The question you need to address firstly is why you are considering suddenly changing to medicine or neuroscience. If it's "because they have better prospects" then immediately disregard that idea and stick with what you are doing. Fundamentally you could get a degree in e.g. Cuneiform Studies and still do very well for yourself, if you get a good degree classification and a lot of relevant internships/work experience/placements/etc while you are on the degree. Most grad schemes do not care what you studied at uni. You can go into investment banking, accounting, media, business/management, the civil service, law, etc, and many other "lucrative" professions having studied anything at all.
If you have done e.g. medical work experience and realised it's your "calling" then do whatever you need to do in order to meet the requirements; you may be better off sticking with your current subjects then taking biology and/or chemistry in a gap year(s) for example. Only taking one or the other will still leave you very, very few medical schools to choose from when applying to anyway so you may be better off just getting excellent grades initially then applying to medicine with a gateway year (i.e. "subject changer" foundation year medicine courses) and/or Newcastle (which has no required subjects for medicine). So even in this case it may be better to stick your current course though - especially if by changing now you run the risk of either a) getting worse results in one or more subjects (which would likely require you resit and then be doing the gap year anyway) or b) having to take your set of three original A-levels over more than 2 years (which medical schools really don't like).
might have some thoughts on the medicine side of things. My perspective is that if you are enjoying English lit already you should stick with it, then figure out how to connect the dots for medicine if need be. For neuroscience it's even less relevant because neuroscience (and in fact, most STEM degrees) are widely available with foundation years for people who took the "wrong" subjects in uni - some examples include Southampton, Manchester, Birmingham, Leeds, etc...