warfarin

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anon8022
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#1
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#1
does anyone know why is warfarin given orally? with reasonable back up evidence?
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black tea
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#2
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#2
orally as opposed to?
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elixirhtc
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#3
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#3
Hmm not sure about it ...
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Zarek
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#4
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#4
Because it gets in to bloodstream this way, it works and this is the easiest way for adults to administer a drug
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mqb2766
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#5
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#5
(Original post by anon8022)
does anyone know why is warfarin given orally? with reasonable back up evidence?
Personal rather than "academic" knowledge. It was discovered after cows became sick/died after eating mouldy sweet clover, so it obviously works orally. This was back in ~1920s-1930s. It was first used as a rat poison, so pill / powdered from was what was sold and only later used for clotting, so I guess a pill was a natural way to sell it.
https://www.pmlive.com/pharma_news/h...arfarin_485464

Can't guarantee that the above is 100% accurate, but ...
Last edited by mqb2766; 2 weeks ago
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NJA
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#6
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#6
It was medicine to thin blood to prevent clots.
Now replaced by rivaraxabsn
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Napp
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#7
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#7
(Original post by NJA)
It was medicine to thin blood to prevent clots.
Now replaced by rivaraxabsn
It hasnt been replaced, its still widely used.. as with several other blood thinners.
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