Well, when you really get down to it, existence is kinda pointless, so it has to be up to you to make it something of it and make it mean something to you.
Coming to terms with the reality that one day we simply stop living is a huge part of human pain.. and a large part of why you get people having their mid life crisis, when they realise how much time they have spent badly and their options are going to be progressively limited as they age further.