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Genetics, Pedigree questions

Hi, I am terrible at this topic in genetics can anyone help? I am still attempting to figure it out myself. The question is a little bit long.

Produce a pedigree diagram to convey the information shown in italics below. Follow the conventions explained to you in teaching sessions and supplied as part of the learning material. You may use the 'Proband' application to produce your pedigree, hand-draw it., or use any other suitable means. You may use any software or system that suits you, but keep the process simple to produce a neat, correct pedigree, swiftly. Save your diagram as a picture file and insert it into the document that you will submit for your assignment.

Brian is 15 months old. He has recently been was diagnosed with X-linked ichthyosis. He is in the clinic with his family to receive the results of the genetic testing. The testing has been done to find out if Brian has an inherited or sporadic form of the disorder. Faisal and Nadia, Brian’s parents, are worried because they are expecting their second child, another boy, in about 3 months. Nadia’s medical notes reveal that she experienced significant post-natal depression after Brian’s birth. The clinician informs them that Nadia is a carrier of a causative mutation and asks them for a family history.
Nadia explains that she has an older sister and that her mother miscarried a baby at about 16 weeks before going on to conceive Nadia. Nadia’s sister is married and has one healthy daughter aged 6. Nadia and her sister lost contact with their mother after she left their dad, but they are still in touch with their maternal grandmother, Lily, who has an identical twin, Hannah. Lily and Hannah both married young and each had two children. Hannah had a girl, then a boy and Lily had a boy, then a girl. Nadia tells you that Lily’s son, Leo (Nadia’s maternal uncle) died very young but that she doesn’t know what of because Lily did not like to speak of it. Nadia tells you that her grand-maternal Aunt Hannah’s youngest child, Eman, has Down Syndrome. He lives quiet and independent life in supported housing. Eman’s older sister, Pearl, didn’t marry but had two daughters by two different fathers. The first daughter has twins (runs in the family). Nadia sees the younger daughter, Asma, quite often; they are going to anti-natal classes together. Asma has one son who is aged 7 and is expecting another boy about a month after Brian’s brother is born.
The clinician asks if Nadia would be willing to disclose her genetic status to her wider family. She says that she is willing. Then the clinician asks if Nadia will supply contact details for Lily, Asma and Jo, to enable the hospital to contact them and ask them to consider genetic testing for the X-linked ichthyosis causing mutation. Nadia agrees. She doesn’t have details for Jo, but she will ask Asma. The clinician explains that Asma’s older sister should be informed too and anyone else who might be a carrier. Nadia is unable to say whether her mother has had more children.
Faisal informs you that he is red-green colour-blind and asks if that matters. You draw the fully annotated pedigree for the clinician and genetic counsellor to use in this case.

3) With reference to the story above and the pedigree diagram that you have produced: What is the approximate percentage chance that Asma’s unborn son will exhibit the X-linked ichthyosis phenotype due to inheriting the causative mutation, if it was carried by Brian’s maternal great-grandmother? Please give your answer as a PERCENTAGE TO ONE DECIMAL PLACE

4) With reference to the story above and the pedigree diagram that you have produced: What is the approximate percentage chance that Nadia’s 6-year-old niece will carry the X-linked ichthyosis causative mutation, if it was carried by Brian’s maternal great-grandmother? Please give your answer as a PERCENTAGE TO ONE DECIMAL PLACE
Original post by TSRStudent99
Hi, I am terrible at this topic in genetics can anyone help? I am still attempting to figure it out myself. The question is a little bit long.

Produce a pedigree diagram to convey the information shown in italics below. Follow the conventions explained to you in teaching sessions and supplied as part of the learning material. You may use the 'Proband' application to produce your pedigree, hand-draw it., or use any other suitable means. You may use any software or system that suits you, but keep the process simple to produce a neat, correct pedigree, swiftly. Save your diagram as a picture file and insert it into the document that you will submit for your assignment.

Brian is 15 months old. He has recently been was diagnosed with X-linked ichthyosis. He is in the clinic with his family to receive the results of the genetic testing. The testing has been done to find out if Brian has an inherited or sporadic form of the disorder. Faisal and Nadia, Brian’s parents, are worried because they are expecting their second child, another boy, in about 3 months. Nadia’s medical notes reveal that she experienced significant post-natal depression after Brian’s birth. The clinician informs them that Nadia is a carrier of a causative mutation and asks them for a family history.
Nadia explains that she has an older sister and that her mother miscarried a baby at about 16 weeks before going on to conceive Nadia. Nadia’s sister is married and has one healthy daughter aged 6. Nadia and her sister lost contact with their mother after she left their dad, but they are still in touch with their maternal grandmother, Lily, who has an identical twin, Hannah. Lily and Hannah both married young and each had two children. Hannah had a girl, then a boy and Lily had a boy, then a girl. Nadia tells you that Lily’s son, Leo (Nadia’s maternal uncle) died very young but that she doesn’t know what of because Lily did not like to speak of it. Nadia tells you that her grand-maternal Aunt Hannah’s youngest child, Eman, has Down Syndrome. He lives quiet and independent life in supported housing. Eman’s older sister, Pearl, didn’t marry but had two daughters by two different fathers. The first daughter has twins (runs in the family). Nadia sees the younger daughter, Asma, quite often; they are going to anti-natal classes together. Asma has one son who is aged 7 and is expecting another boy about a month after Brian’s brother is born.
The clinician asks if Nadia would be willing to disclose her genetic status to her wider family. She says that she is willing. Then the clinician asks if Nadia will supply contact details for Lily, Asma and Jo, to enable the hospital to contact them and ask them to consider genetic testing for the X-linked ichthyosis causing mutation. Nadia agrees. She doesn’t have details for Jo, but she will ask Asma. The clinician explains that Asma’s older sister should be informed too and anyone else who might be a carrier. Nadia is unable to say whether her mother has had more children.
Faisal informs you that he is red-green colour-blind and asks if that matters. You draw the fully annotated pedigree for the clinician and genetic counsellor to use in this case.

3) With reference to the story above and the pedigree diagram that you have produced: What is the approximate percentage chance that Asma’s unborn son will exhibit the X-linked ichthyosis phenotype due to inheriting the causative mutation, if it was carried by Brian’s maternal great-grandmother? Please give your answer as a PERCENTAGE TO ONE DECIMAL PLACE

4) With reference to the story above and the pedigree diagram that you have produced: What is the approximate percentage chance that Nadia’s 6-year-old niece will carry the X-linked ichthyosis causative mutation, if it was carried by Brian’s maternal great-grandmother? Please give your answer as a PERCENTAGE TO ONE DECIMAL PLACE


I’ve tired to draw it 4 times but each time my answer is different

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