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Alice2411
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#1
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#1
If i said an enyzme was degraded, does that mean the same as denatured?
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oxymoron
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#2
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I would associate degradation with the actual breakdown of the primary structure (ie peptide bonds broken), whereas denaturing is the breakdown of the tertiary structure (ie protein shape).
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anchemis
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#3
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err... depends on degradation... sometimes enzymes degrade due to excessive use... no catalyst can be used indefinitely...... denaturation is the break down of the bonds holding the amino acids in place and thus affecting the shape...
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Fluffy
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#4
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I'm with oxymoron - degredation usually equals destruction of structure/sequence - protein degredation is a little more that just a break down on the bonds, it's a breakdown of the material - frequently by ubiqutination.

Degradation is more related to functional loss of activity - some denatured enzymes can be renatures and return to full activity under certain conditions
i.e. lysozyme + 8M Urea + 2-mercaptoethanol ---> denaturation = 'random coil' ---> dialysis ---> renatured fully functional lysozyme.
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Golden Maverick
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(Original post by Fluffy)
I'm with oxymoron - degredation usually equals destruction of structure/sequence - protein degredation is a little more that just a break down on the bonds, it's a breakdown of the material - frequently by ubiqutination.

Degradation is more related to functional loss of activity - some denatured enzymes can be renatures and return to full activity under certain conditions
i.e. lysozyme + 8M Urea + 2-mercaptoethanol ---> denaturation = 'random coil' ---> dialysis ---> renatured fully functional lysozyme.
I think you mean denaturation?
I agree though with you two.
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Fluffy
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(Original post by Golden Maverick)
I think you mean denaturation?
I agree though with you two.

Yes I did - I was typing in a hurry as I needed to go out!

And I think you meant 'too' :p: (dorry I am a pedant!)
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oxymoron
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lol ... he could have meant two I suppose if he meant you and me .... ? (and you thought YOU were a pedant! :p:)
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Golden Maverick
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(Original post by oxymoron)
lol ... he could have meant two I suppose if he meant you and me .... ? (and you thought YOU were a pedant! :p:)
That is what I meant, lol, is there something about scientists and pedantry?
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Fluffy
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#9
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Damn... racks brains for a pedantic come back... can't think of one, goes out for a fry up
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