1. Most unis will tell you their min. GCSE requirements and unless they have a ranking system- you only need the minimum grades (eg. manchester 5 7's). So if you have higher- you won't be advantaged in any way so as long as your predicted also match up- you'll be fine, just check out their requirements. 2. An excellent UCAT will definitely put you in a good position- but you have to research what your unis selection process is (ranking ucat first, or GCSEs first?). and again a mixed set of GCSEs will not disadvantage you as long as you have the min requirements. But they usually have specific requirments for gcse english and maths- so be wary of that 3. Ucat thresholds change from year to year- getting slightly higher every year. check out the ucat page for previous years results and research your unis previous ucat cutoff/ threshold- this should give you a good idea. some unis will be more lenient- others will not, so apply strategically. personally, i would aim for 2700-2800 and above to be in a good position, however it is not the end of the world if you get slightly lower- just apply strategically!!! 4. Applying after you've done your a levels is a personal choice. 5. Sometimes unis say that you can apply max twice if you get rejected pre interview however I dont think there is an explicit disadvantage if you have been rejected before. Check out the unis page. If rejection was due to a level results, you probably won't reapply to that same uni anyways, however if it was due to a low ucat, you may wish to apply again the following year if you get a higher result. Hope this helped!!