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Need help understanding a scientific concept

Hi, please could someone explain this to me? It’s got to do with epigenetics but I don’t really get the part highlighted in yellow? So there’s been a recent article on how cancer may not be cause by mutations but by epigenetics but I don’t understand because the part in yellow about there being a depletion of protein, would that not be caused by mutations? How else could the protein be depleted?
Here is the highlighted bit: https://app.gemoo.com/share/image-annotation/643689468911796224?codeId=PYlywbkN7zoAB&origin=imageurlgenerator&card=643689467137605632

And the whole article for reference: https://www.genengnews.com/topics/cancer/cancer-can-form-without-genetic-mutations-just-epigenetic-changes/#:~:text=This%20possibility%20was%20explored%20by,inheritance%20of%20altered%20cell%20fates.
There’s also this article which I really want to read but can’t access it and its got do with the topic :frown: https://www.nature.com/articles/d41586-024-01019-2
Thanks!!
https://www.nature.com/articles/d41586-024-01019-2

If you know the title of this paper? enter it in search field at:
PubMed (nih.gov)
You will probably get a full-text .pdf FOC!
Original post by macpatgh-Sheldon
https://www.nature.com/articles/d41586-024-01019-2
If you know the title of this paper? enter it in search field at:
PubMed (nih.gov)
You will probably get a full-text .pdf FOC!

I’ve entered it Tumours form without genetic mutations” but there is no pdf version attached?
Original post by anonymous294
I’ve entered it Tumours form without genetic mutations” but there is no pdf version attached?
Good morning Mr/Miss Anonymous,
Ok it seems this full-text article is not FOC [just your luck - sorry!]

However dw - there is always a way!

Are you a uni student? If so, you can ask for a Shibboleth or other login password from your uni library [some schools might have one, too].[you might need to request a Springer Nature pw]

Then login here using above, and chances are v high you will access it [scroll down by about 3 cm and you will see login link]!
Tumours form without genetic mutations (nature.com)

Springer Nature account - log in or register

M
Reply 5
Original post by anonymous294
Hi, please could someone explain this to me? It’s got to do with epigenetics but I don’t really get the part highlighted in yellow? So there’s been a recent article on how cancer may not be cause by mutations but by epigenetics but I don’t understand because the part in yellow about there being a depletion of protein, would that not be caused by mutations? How else could the protein be depleted?
Here is the highlighted bit: https://app.gemoo.com/share/image-annotation/643689468911796224?codeId=PYlywbkN7zoAB&origin=imageurlgenerator&card=643689467137605632
And the whole article for reference: https://www.genengnews.com/topics/cancer/cancer-can-form-without-genetic-mutations-just-epigenetic-changes/#:~:text=This%20possibility%20was%20explored%20by,inheritance%20of%20altered%20cell%20fates.
There’s also this article which I really want to read but can’t access it and its got do with the topic :frown: https://www.nature.com/articles/d41586-024-01019-2
Thanks!!

Epigenetic changes are those that affect gene expression, but do NOT affect the genetic code. Examples of these changes include methylation and histone modification. These changes can increase or decrease gene expression. Now imagine that these epigenetic changes increase the expression of an oncogene, or decrease the expression of a tumour suppressor gene. This will drive tumourigenesis in the same way as mutations, without actually changing the genetic code itself.

Oh unfortunately I’m not in uni but thank you!
Original post by Jpw1097
Epigenetic changes are those that affect gene expression, but do NOT affect the genetic code. Examples of these changes include methylation and histone modification. These changes can increase or decrease gene expression. Now imagine that these epigenetic changes increase the expression of an oncogene, or decrease the expression of a tumour suppressor gene. This will drive tumourigenesis in the same way as mutations, without actually changing the genetic code itself.

Ohhh that makes sense thank you!

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