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University Project Inquiry: SR9009 Bioavailability and Formulation Optimizat

Hello Gentlemen and Lady’s,
I am aware of the ongoing debate regarding whether SR9009 truly possesses any significant oral bioavailability (above 2.2%). To ensure optimal administration, I am considering formulating a solution in the form of drops using distilled water. Would it be advisable to include a pH buffer or an emulsifier in the preparation to enhance stability and absorption? SR9009
Chemical Name:
3-[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidine carboxylic acid ethyl ester

Other Ingredients:
1. Gelatin
Function: Used to make the capsules. Gelatin is an animal-derived protein commonly employed as a capsule material in dietary supplements.
2. Magnesium Stearate
Function: A common flow agent used in tablet and capsule manufacturing. It prevents powders from clumping and ensures even distribution during production.

I am a pharmacology student in my 4th semester at the Faculty of Medicine (Comenius University) in Bratislava, Slovakia. Here, the availability of research chemicals, even for private individuals, is very permissive.
I think you should definitely include some sort of pH buffer as not only will that increase absorption and stability but it is something you can prepare with materials that are not too scarce if that makes sense.
Original post by PainPainPain
Hello Gentlemen and Lady’s,
I am aware of the ongoing debate regarding whether SR9009 truly possesses any significant oral bioavailability (above 2.2%). To ensure optimal administration, I am considering formulating a solution in the form of drops using distilled water. Would it be advisable to include a pH buffer or an emulsifier in the preparation to enhance stability and absorption? SR9009
Chemical Name:
3-[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidine carboxylic acid ethyl ester
Other Ingredients:
1. Gelatin
Function: Used to make the capsules. Gelatin is an animal-derived protein commonly employed as a capsule material in dietary supplements.
2. Magnesium Stearate
Function: A common flow agent used in tablet and capsule manufacturing. It prevents powders from clumping and ensures even distribution during production.
I am a pharmacology student in my 4th semester at the Faculty of Medicine (Comenius University) in Bratislava, Slovakia. Here, the availability of research chemicals, even for private individuals, is very permissive.

Are all those all the ingredients so far?

To just check my understanding of your proposal, you are planning to make capsules from the gelatin and magnesium stearate and to put a 2.2% w/v solution of SR9009 inside. Given the apparent water-solubility of SR9009 is under 1.2 mg/ml or 0.12 g / 100 ml (according to ChemSpider), you won't be able to make a 2.2% w/v solution or a 2.2% w/w solution (assuming I have understood your idea correctly) that way. As such, you may want to include something to improve its solubility. Whether you include a pH buffer or not I cannot tell you as I am no pharmacist and have no clue whether this either prevents hydrolysis whilst in solution (not that this is a particularly likely problem) or whether it maximises the uptake of the drug. You would also need to work out what sort of pH you are going for as this will help you choose the right buffering agents.

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