I commuted from Glasgow to Edinburgh for uni and it was undeniably brutal. (It was the best/one of few places that offered my course and moving there just wasn't practical)
As above, using the M8 in the morning or evening rush can ruin your day entirely, when it or the bypass slows down it can easily add 30-60mins to your trip.
I found the train just about doable, but this still meant being up at half 5 most day to leave and get my first train to central at half 6, and then desperately hoping it makes it in in time to run and catch the London train via Edinburgh (missed it a few times), I'd get to Edinburgh about 8ish and then had to hike up the mound to get a final bus to my campus in Blackwood.
Big downsides is the obv 4-6 hours a day and cost for the commute, even for a half day and you'll be raging if they send the class home early or for free study. You'll start to sorely miss this time for both study and yourself, and yeah with that commute ahead of me I generally never had any interest in staying after class to do anything. All the legs of the journey are just long enough to be boring but too short/busy to be of any real work use beyond skim reading.