how bad do you think a 2 and a half hour journey to uni is?

Is this one way or total for both ways, and do you need to go in every day?

I wouldn't do it or be able to do it. Will very much depend on the content-level and difficulty of the course.

Only thing I would be worried about is the cost.
About a year ago, I left my job to do my Masters (it was full time and was doing it for three years after graduating from my BSc).
The journey took me about 2 hours but it was a single bus ride, so cost me about £180 for 3 months worth of travel, so I thought the savings were worth the travel.
So think of it that way, is the ease and cost even as I assume you don’t pay rent (forgive me if wrong but I assume you live with your parents/guardians)?

One bus honestly sounds fantastic. Mines a tube and then the national rail (which takes up majority of the journey)Which I dont mind to much as I can study during it. But yes the cost is a little crazy, around 6k anually, and i've got to leave my job to. I could afford it with a little help from sfe, but its just all that added together i feel people are gonna look at me a little crazy.
(and yeah I live with parents and dont pay rent )

Are you going to be travelling by bus, train or driving?
The cost is going to be a consideration for sure. But at least on the bus/train you will be able to study. I used to drive 1.5 hours each way and that was about my limit- it meant I spent a lot of time travelling each week and that eats into study time. You may be able to counter this by using a pretty solid ready-made anki deck specific to your school so your total study time may be better employed than my own.

If you have a 2+ hour journey by rail how are you going to cope when you are past the clinical years and in placement and have to be on site by 0800? You say you have caring responsibilities but even at the end of the 5 years you will be in full time work and might not be placed in F1 anywhere near home?

One bus honestly sounds fantastic. Mines a tube and then the national rail (which takes up majority of the journey)Which I dont mind to much as I can study during it. But yes the cost is a little crazy, around 6k anually, and i've got to leave my job to. I could afford it with a little help from sfe, but its just all that added together i feel people are gonna look at me a little crazy.
(and yeah I live with parents and dont pay rent )

So I'm going to assume for the sake of it, you live in/around London (inner, outer or on the fringe) and then get the tube to somewhere like London St. Pancreas or Brighton way (if from Victoria) or something out of London, possibly somewhere near the midlands or something.
You'll have more free time admittedly by moving but your expenditure will be more than £6k, think rent, bills, food (very nice to have dinner waiting for you when you walk in than cook when you get in after a day out) and travel when there. You will also have to spend time cooking, cleaning and I can admit, housemates can be luck of the draw at the best of times (I've lived (currently also living) with people who can't clean up after themselves (not a student right now but moved away from home as I was offered a golden ticket job offer, however, for "professionals", these people don't know how to clean up the mess they leave in the kitchen...)).
I've lived with housemates who kept to themselves, sociable ones, ones who played their guitar at 2am... an abundance of them (including hearing them having sex in the room next door, or when I was cooking dinner).
So, you can weigh up the pros and cons to be honest or if you want to try it in your first (or possible second year once you've had time to get used to deadlines and what is expected of you (I assume first year)), it might be worth taking what you know and deciding if it's worth doing or not.
Good luck!

I always take the view that where there is a will there is a way but I do not look fondly on a 6am drive to Uni every day in first year.
There are virtually no reasons you could convince me to drive to the centre of a major city every morning for 5 years. If the train is reliable and you can actually spend productive time studying on it, that sounds almost like a dream compared to what I endured.
Of course the other issue with living at home whilst at University is that you will completely miss out on any social aspect of being at University in the main. That might not be big deal for some people, however.

Congratulations on studying Medicine. This commute is very demanding. I drive an hour and find it tiring, particularly in winter. But as you say if you are using public transport you can use most of the time for other things. If you’ve got this far you’ll find a way to make it work. I would give thought to alternatives if it does prove too much though