Yes, fortunately they do take extenuating circumstances into account. I can confirm this as this has literally happened to me this year. I’ve received an offer from Warwick and I didn’t do great GCSE’s either due to extenuating circumstances; achieved a 5 in English language and averaged 6’s on the rest (I even had a 4 in art, although it’s an irrelevant GCSE, a 4 is still a bad look on your profile). I always wanted to go to a target university but I always thought I had no chance due to having a mediocre set of GCSE’s, which really saddened me. I applied either ways but made sure to contact the admissions team beforehand to explain my situation and ask whether they’d still consider me and have all the right information. I applied for PPE (an extremely competitive course) and I still got an offer! So anything is possible despite your circumstances. My only advise is that you have to work extremely hard. I was failing all my subjects at the start of year 12 (even Spanish when I’m literally Spanish💀) but then I locked tf in and got amazing predicted grades. Don’t give up, anything is possible (with God ofc), just work hard from now onwards.