transwell co-culture fibroblast

Kristenyu

2

when I want to explore the influence of fibroblasts on the growth of epithelial cells

Reply 1

Nitrotoluene

12

Original post

by Kristenyu

when I want to explore the influence of fibroblasts on the growth of epithelial cells

You raised an interesting point: the link between epithelial cells and fibroblasts. This link is incredibly important in so many biological processes.
The three general mechanisms by which fibroblasts can influence epithelial cells involve:
1. Secreted factors
2. Contact with another cell via cell-to-cell adhesion
3. Extracellular matrix (ECM) secretes as many fibroblasts as are related to the ECM.
Let's look at the first one: secreted factors. What are the general types of secreted factors that fibroblasts might secrete to affect epithelial cells?
Maybe consider the general types of molecules cells use to talk to other cells.
Here is my 2 cents!
Ciao,
Sandro

Reply 2

Kristenyu

OP

2

Original post

by Nitrotoluene

You raised an interesting point: the link between epithelial cells and fibroblasts. This link is incredibly important in so many biological processes.
The three general mechanisms by which fibroblasts can influence epithelial cells involve:
1. Secreted factors
2. Contact with another cell via cell-to-cell adhesion
3. Extracellular matrix (ECM) secretes as many fibroblasts as are related to the ECM.
Let's look at the first one: secreted factors. What are the general types of secreted factors that fibroblasts might secrete to affect epithelial cells?
Maybe consider the general types of molecules cells use to talk to other cells.
Here is my 2 cents!
Ciao,
Sandro

Thanks very much! And now I'm looking for a protocol about it. Could you give me some suggestions?

transwell co-culture fibroblast

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