I just have one folder now, which I take to all my lectures, which is partitioned for each subject. When it gets full, I'll put the older notes into seperate course-specific folders, which will just clutter up the floor in the meantime.
When I was in 6th form, I had a reputation for carrying all my folders, notes, and relevant textbooks in one big backpack to all my lessons. I said it was easier than working out which stuff to pack when I was departing in a rush in the mornings...