Nooooooo, you need Grannies! Their upgrades makes them one of the best buildings in the game to have (to a certain point). My Grannies produce more cookies per second than everything bar the Antimatter Condensers and Prisms, they're a must have!
Also, the Wrinkler effect is something seriously worth considering...
http://cookieclicker.wikia.com/wiki/Wrinkler"Wrinklers can be killed, or popped, by clicking on them at least three times. When one is popped, it will drop the number of cookies it has sucked over its life multiplied by 1.1."
So despite the initial drain, upon popping them you actually end up with more cookies than you would have without them. Nifty
I pop mine every 4-5 quintillion cookies or so, I think I ended up with nearly 50 quintillion total cookies after popping all of them.
The Grandmapocalypse also brings its own benefits (and drawbacks) with it.
http://cookieclicker.wikia.com/wiki/GrandmapocalypseI didn't copy and paste my stats either, they were all copied out by hand (had some time to kill).
It's also worth mentioning that my game has been attained all the while I'm online; I've never left it running overnight. Coz, y'know... 1337, etc.