Muscarinic antagonists

I am just going over one of my lectures on muscarinic receptor antagonists. I have covered atropine which can be used as a treatment of bradycardia as it blocks parasympathetic activity and now i am looking at hyoscine which apparently can be used as an anaesthetic premedication as one of its properties is it decreases heart rate and contractility. Why does this muscarinic antagonist do the opposite to atropine?

Reply 1

Renal

17

I thought it's anaesthetic uses were for it's secretory & hypnotic effects.

Reply 2

nexttime

22

Isn't it M1 specific? :dontknow:

Reply 3

Demon_AS

13

joshwaah

I am just going over one of my lectures on muscarinic receptor antagonists. I have covered atropine which can be used as a treatment of bradycardia as it blocks parasympathetic activity and now i am looking at hyoscine which apparently can be used as an anaesthetic premedication as one of its properties is it decreases heart rate and contractility. Why does this muscarinic antagonist do the opposite to atropine?

As I recall, Hyoscine is an anti-emetic... no? So, I'm guessing it works on a different M-class receptor than atropine does.

Muscarinic antagonists

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