Maybe it's more of a case of using the right mouse or keyboard. For a long time, I used an Apple mouse (yes, that's right) that was expectedly awful until I finally took the plunge and bought a dedicated gaming mouse for the game (a testament to my obsession), which has helped tremendously.
It's worth noting that I'm specifically referring to Quake Live, not any other FPS game. For this game, a mouse and keyboard is really the only option.
Aha, fair enough. If you do get it working, post here or chat to me on MSN. Would be good to get a few games going. My name on there is Seirei.