So, I see that these posts are from quite awhile ago now, but just incase anyone else is looking into amitriptyline and alcohol and stumble upon this thread.. I wanted to share my reaction. Im currently on 20mg of amitriptyline for migraines. I was taking 10mg for 2 weeks, and sized up to 20mg starting about 2 1/2 weeks ago. Now, I've had a glass of wine here and there while taking this and had no adverse effects. However, amitriptyline does not make me tired. In fact my Dr had me switch from taking it before bed, to taking it first thing when I wake up on the morning. Yesterday was a very stressful day, as I spent it with my mother.. so when a good friend of mine asked me if I'd like to go for a drink, I quickly agreed. I consumed 3 1/2 lemon drops (basically just lemon vodka) in roughly 2 hours. I got up and went to the bathroom, barely feeling drunk at that point. And then woke up in the hospital. I had lost consciousness, hit my head, presumably had a seizure, and vomited profusely. All of which prompted a call to paramedics and a stay in the hospital. My blood alcohol level wasn't even high enough to be considered legally drunk. But I was completely out of it, I hardly remember anything between heading to the bathroom and waking up in the ER. So to anyone at all who just might be trying to read up on mixing amitriptyline and alcohol, I am here to warn you, please please.. do not. And if you do, make sure you have a friend with that you trust and that knows about your medication. Godspeed.