It will be fine for most unis but not others. There are a few that specify biology, but they may have higher entry requirements anyway (BBB) and/or want GCSE science at grade B, which she doesn't have of course. Here in the north-west, for example, Liverpool ask for BBB including biology, and also want GCSE science grade B. Manchester want BBC and want a science, but are fine with health and social care as the science subject. But Liverpool John Moores want 280 points, with no subjects specified, as do UCLan (BCC or equivalent). If she were to do biology she might struggle to do really well in it from only having C at GCSE - especially if she goes to a college she doesn't like! It would be a real shame for her to do biology and do poorly at it, when she could really enjoy and excel at a different subject. As the post above says, it may put her mind at rest to check directly with the unis she is interested in. Also, don't forget that GCSE Maths and English (or equivalent) are also mandatory at C or above - I assume she has these in the bag (though my sister got into nurse training years ago without Maths O level, as it wasn't required then - and is still a fantastic nurse 30 years later!).