Factors affecting speed of transmission in a neurone
The action potential remains the same size as it moves throughout a neurone; however, factors can affect the speed at which an action potential is propagated. These are as follows:
1. Myelination. Myelination means that saltatory conduction can occur, because myelin provides electrical insulation, meaning that action potentials can only be generated between separate nodes of Ranvier, as opposed to between localised electrical circuits. Therefore, the action potential is propagated faster in a myelinated neurone.
2. Temperature. Temperature affects the rate of diffusion of ions; the greater the temperature, the greater the rate of diffusion of ions. Furthermore, the sodium-potassium pump functions by means of active transport, and, therefore, it requires ATP for this process. ATP is made as a result of respiration, which is an enzyme-controlled process. The greater the temperature, the greater the rate of enzymatic action and the greater the rate of respiration; this will quicken the rate of ATP production, which will in turn increase the rate at which the sodium-potassium pump functions. This is less of a consideration in endothermic animals, which can maintain a relatively constant internal body temperature, but is a consideration in ectothermic animals, whose temperature varies with the environmental temperature.
3. The diameter of the axon. The greater the diameter of the axon, the faster the rate of conductance; this is because there is less leakage from a larger axon. Leakage makes membrane potentials harder to maintain.