Dale Cooper/Albert (Twin Peaks)
Kolchak (Kolchak: The Night Stalker)
Mycroft/Sherlock Holmes (any appearance they make basically, they pop up a lot)
The Doctor (Doctor Who)
Arcade Gannon/pretty much any companion or Mr House (Fallout: New Vegas)
Agent York (Deadly Premonition)
Geneviève Dieudonné (Anno Dracula)
Tom Reagan (Miller's Crossing although nearly all of them deserve a place)
Caius Martius (Coriolanus)
Professor Quatermass (Quatermass serials)
Kino (Kino's Journey)
Eric Taylor (Friday Night Lights)
Malcolm Tucker (The Thick of It)
Omar (The Wire)
Motoko (Ghost in the Shell: Standalone Complex)
Johnny (Naked)