I've taken both Chemistry and English Literature, and I'll warn you now that these courses are the hardest ones, both in terms of learning the course and workload.
It depends which subject you're going to drop for A2, if at all. All of the universities I've seen wanted Chemistry and one other science for medicine, so either track will be alright for that if you plan to drop History.
Sometimes mixing science and arts doesn't work. I'd say take the first option, and at the end of AS review if you want to be a doctor or English teacher and take it from there.