Do you know what sort of career you want at the end of it because that can really sway your decision.
Though saying that I wouldn't let it rule your decision because I had a friend who had wanted to be a vet all her life but halfway through the first year of college she realised this was the wrong decision as she doesn't actually like science, just helping animals! This meant that she had to do a history a level in one year instead of two to make sure she had the qualifications to get onto the degree she actually wanted to do.
My experience got me to Uni but I am going to withdraw from my course (physics) and reapply next year to do what I enjoy (design), not what I think is practical/will lead to a good career. And I can tell you this is not a good situation to be in, it would have been a lot easier to make the right decision the first time around!
I don't want to scare you though, me and my friend are pretty much exceptions to the rule, most of the people I know have gone on to Uni, or I've met at Uni, and are really happy with the choices they made.
There is a point to this reply, honestly, and that is to pick what you love straight from the beginning without wondering whether it's practical or will work, because if you enjoy it then you'll make it work for you.
As far as courses go, I did Physics, Maths, Further Maths, Philosophy and Ethics, DT so if you have any questions about those in particular I'll do my best to answer them for you