I am 45 and have had this issue for years. It seems to have gotten worse as time goes on. When I was a teen, I could handle a drink or two without all of the shaking, etc. Someone mentioned it feels just like an anxiety attack but just in the body, I have to strongly agree. As I have gotten older and as of late, it only takes a few sips of wine to throw me into a complete spin. About 30 minutes after the first sip, my stomach starts to chirn, I end up in the bathroom (I will leave the details out here, but I'm sure you can guess and no.. I'm not puking, two sips of wine doesn't cause nausea or drunkenness). Then.. approximately 6 hours of shaking and teeth chattering. However, I don't feel cold, just annoyed. That being said, I do feel better and validated that this isn't just something that happens to me. I have asked doctors why this might happen and they all look at me in complete bewilderment. Nor do any of my friends understand why I refuse to drink. This issue is largely unheard of and honestly, now that I know I'm not the only one, I feel that someone should look into this.