Natural uranium contains three isotopes worth bothering about. U-235 and U-238 are primordial; that is they were present in the matter from which the Earth was formed and their half lives are long enough that they survive. U-234 is too short lived to be primordial, but is constantly generated by the decay of U-238.
So uranium separated from ore will be a mixture of U-238 (almost all of it), U-235 (0.71 atom%) and U-234 (0.0054 atom%). Then there are the 22 other artificial isotopes. For each isotope, the mass of the nucleus will be different because it contains different numbers of neutrons, so the question really needs to specify which isotope.