I knew 2 girls that were going - I avoided them at all costs. Excluding a girl I chatted to on Facebook and MSN, the best people I met were in the first 10 minutes, whilst I queued up to register. Seriously, everyone was so friendly, I more or less went round having a chat with all.
If you think about it, a lot of these people are the ones you're going to be at Uni with, and they may well end up being colleagues and friends in the future! Just get out there, start chatting and get introducing - it's really quite easy, even for the shy.