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Binding Kd

Binding Kd

could someone help me answer this?
Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One approach to treating high blood pressures is to administer competitive inhibitors that bind to the a-adrenergic receptor. The Kd for binding of epinephrine to this receptor is ~0.6 mM.

Which of the following compounds might be a good candidate drug for high blood pressure? Their Kd for binding to the a-adrenergic receptor are shown.

Compound A: Kd = 1pM
Compound B: Kd = 60 pM
Compound C: Kd = 0.6 mM
Compound D: Kd = 60 mM
Compound E: Kd = 60 mM

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