I think Jade is possibly talking about me? I got a low C at AS in Chemistry at AS, was predicted an A (after a lot of drama) and then got a high A at A2. Still managed 3 interviews and 2 offers, so yes, it is possible. The predicted grades are much more important and I did have a lot of work experience, so just try and make up for your grades in other aspects of your application.
/procrastination when I should be revising.